What Causes Low Testosterone In Men Over 40?

When a patient has blood work done and it comes back with low testosterone, the biggest questions we get is.. “How did this happen?”

The answer is never simple. As we age, we lose testosterone starting at age 30 or so. Losing 2% to 5% per year. There are a number of reasons why you lose testosterone. More are environment related vs. age related.


The fight or flight mechanism in the brain is triggered during stressful times. When this happens your adrenal gland releases cortisol and adrenaline. When cortisol is released into the body over a consistent period of time, it begins to erode your testosterone levels. Long term periods of stress and anxiety can lower your overall testosterone levels.

Anti Anxiety/Depression Medications

When we are in periods of high stress it can lead to anxiety and depression. To combat this medical issues, the use of anti anxiety medication has risen significantly. However, these medication has shown to block the production of testosterone. Subsequently your testosterone levels take a two part hit. The stress and the medications.

Oh and to make matters worse. Low testosterone is shown to contribute to anxiety and depression in some males.

Cholesterol Medications

With low testosterone, comes a lack of energy. For many men, this means less or no workouts. When we exercise our body releases testosterone. It’s why you want to exercise more the more you exercise. You have more energy. When we don’t exercise we are more likely to have high cholesterol.

Cholesterol medications are shown to block the production of testosterone. Putting the vicious cycle into overdrive.


When we sleep, our body produces testosterone. It’s why testosterone levels are usually at their highest first thing in the morning. As the day progresses, stress levels can increase, causing our testosterone levels to be attacked by cortisol.  Thus lowering our testosterone levels.

If you are not sleeping well at night, your body can not repair itself. Then you wake up in the morning with a testosterone deficit. Starting your day out behind the eight ball.


The last one is simply our bodies. Every physical body is different and you can’t judge a book by it’s cover.

We’ve seen men in their 70’s with testosterone levels above 800 without any supplementation. Other men in perfect physical health in their 40’s with testosterone levels below 100.

The luck of the draw in life factors into your testosterone levels as well.

What to do next

If you are suffering from any of the above, or think you have low testosterone as described in other articles. Then a simple blood test will tell you the answer.

Many of our patients have been surprised by their testosterone levels. Many more have been surprised by the fast results from treatment. (Plus the affordability)

The test results can be delivered to our clinic within 24 hours and a course of treatment designed for you.

If you want to know more, feel free to call the clinic at (919) 578-8700 or request an appointment on this page.

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